Found inside – Page 274As the luminescence of lux-marked bacterial biosensors depends on the products of the electron transport chain for light production, inhibition of this process due to chlorophenol toxicity will result in a decrease in light output. The aim of this ... Found inside – Page 296Mechanism of Inhibition by Antimycin The following effects of antimycin on the heart - muscle preparation are described ... in large excess [ 47 ] or reacts rapidly in comparison with other components of the electron - transport chain [ 68 , 18 ] . Background: Accumulating evidences showed metformin and berberine, well-known glucose-lowering agents, were able to activate adenosine monophosphate-activated protein kinase (AMPK). Found inside – Page 30If it is assumed that under condition of total inhibition of oxygen evolution that only cyclic photophosphorylation is ... carbon pool in the presence of DCMU inhibits cyclic phosphorylation by removal of electrons from the electron transport chain . Found inside – Page 381In this sense one cannot expect a complete inhibition of electron transport reactions by antibodies against B - carotene . ... the site of action of the B - carotene - protein complexes within the electron transport chain are not necessarily identical . Found inside – Page 204electron transport and by this block photophosphorylation as well . The probably best known inhibitor of the photosynthetic electron transport is DCMU which blocks the electron transport chain near photosystem II . The electron flow can be ... Found inside – Page 12What happened to oxygen consumption after adding ADP ? ... Ascorbate can bind to a complex in the electron transport chain and donate electrons to the chain . ... Based on these results and knowledge of where ascorbate binds , can you determine which complex ( I , II , III , or IV ) is likely to be inhibited by rotenone ? This is the textbook only without LaunchPad. Found inside – Page 13Quenching of the fluorescence of 12 - ( 9 - anthroyl ) stearic acid by cytochrome c occurs by an energy transfer mechanism and ... Alkyl - or aralkyl - biguanides exert site - l and - 11 - specific inhibition of oxidative phosphorylation . ... Therefore a mechanism seems conceivable based on alterations of intrinsic properties of the membrane which provides the microenvironment of the electron transport chain . Found inside – Page 9However in such cells substrate accessibility , rather than the respiratory chain , may limit the rate of oxygen utilization . The decreased content of various components of the electron transport chain may be related to inhibition of mitochondrial ... Found inside – Page 17Electron transport chain . of one pair of electrons from the reduced pyridine nucleotide to molecular oxygen results in the ... isse by The electron transport over the respiratory chain is strongly inhibited by cyanide , azide , and carbon monoxide ... Found inside – Page 36Reactive oxygen intermediates are often by products of the electron transport chain in the mitochondria . Their release ... Calcium release form the ER occurs with treatment of drugs like thapsigargin , and calcium ionophore A23187 ( 27 ) . Found inside – Page 116Both NADH and FADH2 enter the mitochondrial electron transport chain for oxidation and subsequent production of ... Under conditions of ischemia or hypoxia , when oxygen delivery to the mitochondria is reduced severely , electron transport is inhibited resulting in a large increase ... a marked increase in total cellular long - chain acylcarnitines analogous to the increase in this amphiphile which occurs ... Found inside – Page 138From these data it is apparent that inhibitory effects of Pb on electron transport occur prior to cytochrome c . ... to Pb involves TCA cycle enzymes or is confined to the nonheme protein and ubiquinone segments of the electron transport chain . Found inside – Page 34Effect of psychosine on the rate of respiration at different segments of the electron transport chain , respiratory control ... The transfer through site I and site III was inhibited by psychosine , whereas the transfer through site II was not inhibited . Found inside – Page 78GAPDH , a key glycolytic enzyme , is sensitive to inhibition by agents of oxidative stress such as super oxide radicals and H2O2 [ 60 ) . ... renal cortical mitochondria , it inhibited the tricarboxylic acid cycle and electron transport chain [ 65 ) . Found inside – Page 101... methyl - 2 - imidazolidinone } inhibits electron transport at two locations in the photosynthetic electron transport chain . The major inhibitory action occurs on the reducing side of photosystem II but a minor inhibitory site has also been located ... Found inside – Page 816When BOH , a substrate whose electrons enter the electron transport chain at or near the first phosphorylation site , is used to support respiration it is seen in Figure 3 ( a ) that all three antihyperlipidemic drugs tested inhibit respiration . Found inside – Page 59causes unstacking of the thylakoids leading to an altered interaction of the electron transport chain components with the ... the most widely used organophosphorous insecticide in agriculture , is a potent inhibitor of PS Il electron transport . Found inside – Page 120HQNO , a specific inhibitor of bacterial electron transport chain ( Haddock and Jones , 1977 ; Taber and Morrison , 1964 ) which acts at the level of cytochromes b , stopps the exponential growth of both strains ( Fig . 1 ) . HQNO also markedly ... Found inside – Page 53Sodium azide inhibited growth at both 2x10-5 and 2x10-6 Inhibition by azide is considered to occur at site III in the electron transport chain , i.e , in the step cytochrome oxidase → 02 : TWO cyanide compounds were used to demonstrate the ... Found inside – Page 975Amino Acid Transport in a Water - mould : The Possible Regulatory Roles of Calcium and N- ( 4 -isopentenyl ) adenine1,2 DANNY ... Transport of all of these amino acids was inhibited by azide , cyanide , and its derivatives and 2,4 - dinitrophenol . These agents normally interfere with metabolism at the level of the electron transport chain and oxidative phosphorylation . ... ( less than 1 mM ) in the absence of exogenously supplied calcium , enhancement of amino acid transport occurs . Found inside – Page 187was inhibited significantly by AFB , and M , except in the nuclear fraction of B , treated rats ( Table III ) . Aflatoxin B , failed to ... The toxins inhibited the electron transport chain and acted as inhibitory uncouplers of oxidative phosphorylation . Extensively revised, the fourth edition of this highly successful book takes into account the many newly determined protein structures that provide molecular insight into chemiosmotic energy transduction, as well as reviewing the explosive ... Found inside – Page 7... member of the electron transport chain in bacterial mitochondria and is thus critical to aerobic respiration . Similarly to CM , CL catalyzes a reaction that occurs in solution ; quantum chemcial ( B3LYP / 6-31 + G * level of theory ) calculations ... Found inside – Page 7Under anoxia , however , NADH can not be consumed via the electron transport chain and PEP concentration declines ( Kobr and ... The sustained production of lactate is possibly prevented by two mechanisms : i ) LDH is inhibited by ATP . Found inside – Page 286Electron paramagnetic resonance ( EPR ) spectra were recorded on a Varian E4 spectrometer with an Oxford ... of UHDBT required for 50 % inhibition was comparable with the concentration of electron transport chains , this indicates a tight ... Found insideand decay processes indicate involvement of the quinone in the electron transfer chain of yeast . ... Noncyclic electron transport and the coupled phosphorylation reaction were strongly inhibited by 3 - ( 3 , 4 - dichlorophenyl )1 , 1 - dimethylurea ... Judging by the fact that " negative temperature effect " actually takes place at the synaptic junctions , it is proposed that the binding of DDT at the above sites ... Found inside – Page 1908Career Development Awardee of the United States Public Health Service . § To whom , at the Oregon address , inquiries should be directed . It has been shown that the antimycin inhibition of the electron transport chain is bypassed through N ... Found inside – Page 333... our understanding of Q function or else reveal that electron transport chains have more diversity than now presented . ... Mellors and Tappel 125 have reported that Q - 6H , and a - T have at least comparable peroxidation inhibitory effects in ... Found inside – Page 1046... and a higher concentration ( 1 x 10-3M , which irreversibly abolished the contractility of papillary muscle ) completely inhibited respiration in the site - I region of the mitochondrial electron transport chain . However , the resulting conclusion ... Found inside – Page 21482851 INHIBITION of ELECTRON TRANSFER IN THE CYTOCHROME b-cl SEGMENT OF THE MITOCHONDRIAL ... Half maximal inhibition of cytochrome c reduction occurs at less than 10 nM UHDBT, indicating near stoichiometric binding of this inhibitor to the b-cl complex. ... We propose this inhibitor interferes with oxidation-reduction of ubiquinone at a site in the b-cl segment of the respiratory chain. Found inside – Page 683 , cytochrome b reduction and P - 870 * reduction after the second slash were both inhibited by myxothiazol . ... Thus the cytochrome bic , region of the C. vinosum electron transport chain now seems more similar to those of purple non - sulfur ... Found inside – Page 53... inhibitor ( La - crown in this investigation ) binds to a specific component in the electron transport chain to form an inhibitory complex . For La - crown the X , value obtained was about 1 per 20 Chl molecules ( see inset Fig . 4 ) . On Chl basis ... Found inside – Page 600The inhibitor is abbreviated RC , in which “ R ” means reticulocyte and “ C ” cytochrome oxidase . ... Table 3 shows the inhibition by RC of various soluble and particulate cytochrome oxidases . Table 2 Properties ... the electron transport chain . Found inside – Page 327Electron transport particle ( ETP ) respiratory chain , was proved by restoring malate contained some fumarase also . ... It is not known with + FAD certainty at this stage whether this inhibition is | due to some component ( s ) present in the super ... Found inside – Page 72It was also observed by them that even in air, NOA could be reduced to NO, provided mitochondrial electron transfer chain is inhibited by specific inhibitors, such as rotenone and amytal. They also found that a brief exposure of wheat leaves to ... By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for ... Found inside – Page 46At lower DNP concentrations , no inhibition was observed , and between 0.6 x 10-6M , and 1.5 x 10 6M , the ... Wessels theorized that DNP may act ( 1 ) as an electron carrier across some gap in the electron transport chain in isolated chloroplasts , ( 2 ) inhibit some reaction which , in ... It occurs as a waste contaminant originating from many industrial sources , is closely related to several currently used ... Found inside – Page 243... sequence , electron transport chain , flutolanil inhibition , antifungal activity , Rhizoctonia Saccharomyces cerevisiae 6086 solani 1304 nibosomes , ribosomal protein MRP7 genes , MRP7 gene cDNA nucleotide sequence , electron transport ... Found inside – Page 16This effect is due to the action of cra strains of A biotype only , and manose and sataemon on the flavoprotein - cytochrome 6 section licin - by the strains of T biotype which do of the electron transport chain . The inhibitory not ferment lactose ... Found inside – Page 254droxybutyrate dehydrogenase, an enzyme involved in the electron transport chain, and reduced electron transport in rat liver mitochondria. In addition, ipomeamarone also inhibited mitochondrial oxidative phosphorylation. Similar activity to ... Found inside – Page 292As mentioned earlier , 1 mM ferricyanide supports swelling when the electron - transport chain has been blocked at higher levels with cyanide or anaerobiosis . ( 4 , 9 ) Inhibition by low concentrations of antimycin A indicates electron passage ... Found inside – Page 684On increasing the concentration of pesticide, lysis of the membranes and uncoupling can be induced. The electron transport chain can also be inhibited, but only with 5-10 times greater concentrations of pesticide than required for uncoupling. Found inside – Page 832In general , higher percentages of inhibition of NADH oxidase than NADH dehydrogenase by the various inhibitory compounds indicate that the latter could be either one of the first enzymes or at the entry point of the electron transport chain of ... Only with 5-10 times greater concentrations of pesticide than required for uncoupling transport chains have diversity... Also inhibited mitochondrial oxidative phosphorylation the inhibition by RC of various soluble and particulate oxidases! 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