Information on the nature of the peer review and availability of the source documents is presented in Appendix 1. The average size of the rabbit dermal irritant patch tests was 1.0, indicating that MSMA is a mild irritant to intact skin. Concomitant administration of the alcohol dehydrogenase inhibitor 4-methylpyrazole with ME or MEA prevented suppression of the PFC response by these glycol ethers. (ABSTRACT TRUNCATED AT 250 WORDS). DEG has also been inappropriately substituted in pharmaceutical preparations for nontoxic constituents, resulting in more than a dozen epidemics of human poisoning, w… Exposure to MEA was affected by its amount used (P = 0.036), and spraying (P = 0.000) and exposure to butoxypropanol was affected by spraying (P = 0.007) and cross-ventilation (P = 0.000). The clipped skin areas of the rabbits were exposed to doses of MSMA for a 24 hours period. Sakurai K, Mikamoto K, Shirai M, Iguchi T, Ito K, Takasaki W, Mori K. J Appl Toxicol. All rights reserved. The in vitro hydrolysis of DGBA in rat blood and its in vivo metabolism and disposition in male Sprague-Dawley rats were studied. Environ Health Perspect. Clipboard, Search History, and several other advanced features are temporarily unavailable. toxicity was also evaluated for each glycol ether in several in vitro and in vivo assays. 102, 443–455). One animal in the RESULTS ETHYLENE GLYCOL MONOBUTYL ETHER 351 TABLE 1 SUBCHRONIC TOXICITY OF ETHYLENE GLYCOL MONOBUTYL ETHER SUMMARY OF BODY WEIGHT RESPONSE Day of study Control 222 EGBE (mg/kg) 885 443 0 235 17232 13 238 15 235 23 3 253 20 245 15 249 16 231 26 6 272 19 267 14 270 19 253 22 13 311 25 309 17 306 241 281 22 b.` … On the basis of the data presented, it is doubtful that any problems of acute toxicity will result from the use of this silicone oil. Glycol ethers should be handled with all the care that should be taken in the safe use of organic solvents. The acute 4-hr LC50 (with 95% confidence limits) for Fischer 344 rats was determined to be 486 (339 to 696) ppm of ethylene glycol monobutyl ether (EGBE) for males and 450 (315 to 645) ppm for females. Effects of repeated inhalation exposures to EGBE in laboratory animals. The purpose of this study was to determine the uptake, metabolism, and excretion of dermally administered glycol ethers as a function of the externally applied dose. 2020 Aug 17;7:100051. doi: 10.1016/j.metop.2020.100051. At ambient conditions, the low vapor pressure of ethylene glycol monohexyl ether (EGHE) allows for a maximum vapor concentration of approximately 85 ppm. 2-Butoxyethanol has moderate acute toxicity and is irritating to the eyes and skin; it is not a skin sensitizer. Oral dosing of adult male F344 rats with the glycol ether 2-methoxyethanol (ME) or its principal metabolite 2-methoxyacetic acid (MAA) results in the suppression of the primary plaque-forming cell (PFC) response to trinitrophenyl-lipopolysaccharide (TNP-LPS). 111-76-2) is a high- production-volume glycol ether. There were no significant biological effects in rats exposed subchronically to 25 or 5 ppm. The results indicate that persons exposing large portions of their skin to butoxyethanol are at risk of absorbing acutely toxic doses. Park J, Yoon C, Byun H, Kim Y, Park D, Ha K, Lee Sm, Park S, Chung E. J Occup Health. It is also used in metal and household cleaners. HHS Toxicol Rep. 2020 Jun 23;7:779-787. doi: 10.1016/j.toxrep.2020.06.007. Epub 2012 Jan 27. ETHYLENE GLYCOL N-BUTYL ETHER may react with bases, aluminum and oxidizing materials. Mice were given various doses (62.5, 125, 250, 500, 1,000, 2,000 and 4,000 mg/kg body weight) of the compounds daily for 5 days/week, for 5 weeks. This CICAD on 2-butoxyethanol was based upon reviews prepared by the National Institute for Occupational Safety and Health (NIOSH, 1990) and the Agency for Toxic Substances and Disease Registry (ATSDR, 1996). At 41.1 ppm, maternal body weight gain was reduced during the exposure period only. The elimination kinetics of 2-butoxyethanol (ethylene glycol monobutyl ether, EGBE) were studied in the once-through isolated perfused rat liver system in the presence and absence of ethanol. This CICAD was approved as an international assessment at a meeting of the Final Review Board, held in Berlin, Germany, on 26-28 November 1997. Data from animal studies have been examined from the standpoint of dose-response relationships and the sensitivity of various animal species, including man, to the effects of this chemical. 2.-Butoxyethanol (CAS no. This site needs JavaScript to work properly. It is not known whether chronic or repeated exposure to ethylene glycol increases the risk of reproductive toxicity or developmental toxicity. Indirect exposure of the general population to 2-butoxyethanol is most likely from inhalation and dermal absorption during the use of products containing the chemical. Chronic or repeated exposure to ethylene glycol may lead to irritation of the throat, mild headache, low backache, loss of consciousness, and nystagmus, all of which resolve if the source of exposure is removed. Toxicol Lett. There were significant depressions of red blood cell (RBC) count (approximately 20% below control values), hemoglobin (Hgb), and mean corpuscular hemoglobin (MCH) concentration and increases in nucleated erythrocytes, reticulocytes, and lymphocytes in males and females of the 245 ppm group. Toxicity and death may occur after drinking even a small amount. Effects of single vapor exposure of EGBE to laboratory animals. IRIS assessment development process. Although only detected once, EGBE air concentrations (n = 4) were high (49.48-58.72mg m(-3)), and close to the Swiss OEL (49mg m(-3)). The results of in vitro studies indicate that human red blood cells are not as sensitive as rat red blood cells to the haemolytic effects of 2-butoxyethanol and 2-butoxyacetic acid and also that red blood cells are more sensitive to haemolysis by 2-butoxyacetic acid than to haemolysis by 2-butoxyethanol. Rats were immunized with TNP-LPS and then exposed 4 and 28 hr later to 50, 100, 200, or 400 mg/kg of glycol ether or EG. 1983 Jun;27(2):91-102. doi: 10.1016/0300-483x(83)90014-8. Therefore, the two substances should be considered as equally hazardous to man. Data from animal studies have been examined from the standpoint of dose-response relationships and the sensitivity of various animal species, including man, to the effects of this chemical. Dermal absorption may contribute substantially to the total uptake following skin contact with liquids or vapours containing EGME or EGMEA. COVID-19 is an emerging, rapidly evolving situation. Somade OT, Ajayi BO, Adeyi OE, Adeshina AA, James AS, Ayodele PF. They are used in paints, lacquers, stains, inks and surface coatings, silk-screen printing, photographic and photo lithographic processes, for example, in the semiconductor industry, textile and leather finishing, production of food-contact plastics, and as an antiicing additive in hydraulic fluids and jet fuel. The effects on the rat testis of single inhalation exposures to ethylene glycol monoalkyl ethers, in particular ethylene glycol monomethyl ether. These 95% commercial antifreeze preparations are diluted ~50% with water when used in vehicle cooling systems. 2. A case of acute poisoning with ethylene glycol butyl ether (EGBE) is reported in a chronic alcohol abuser. eCollection 2020 Dec. Somade OT, Ajayi BO, Olushola MO, Omoseebi EO. Due to the lack of quantitative assessments of respiratory exposures to airborne irritants and sensitizers among professional cleaners, the culpable substances have yet to be identified.Purpose: Focusing on previously identified irritants, our aims were to determine, The 24 day LDââ of monosodium methanearsonate (MSMA) for New Zealand white rabbits was estimated to be 102 mg MSMA/kg body weight. It attacks some forms of plastics, rubber and coatings. 1984 Aug;57:7-12. doi: 10.1289/ehp.84577. EGM was more effective than EGE, while ethylene glycol mono butyl ether and ethylene glycol mono phenyl ether had but slight effect and EG had no detectable action on testis and leucocytes. It is used as a solvent in spray lacquers, enamels, varnishes, and latex paints and as an ingredient in paint thinners and strippers, varnish removers, and herbicides. A tolerable concentration of 11 mg/m has been derived, based upon the benchmark concentration for hematological effects in rats, quantitatively taking into account experimental data on interspecies variations in kinetics and dynamics. The relationship between respiratory failure and EGBE is examined. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. As a relatively nonvolatile, inexpensive solvent, it is used in many domestic and industrial products because of its properties as a surfactant. 1. Data from animal studies have been examined from the standpoint of dose-response relationships and the sensitivity of various animal species, including man, to the effects of this chemical. Ethylene Glycol: The general formula for ethylene glycol is C 2 H 6 O 2. Gestational parameters monitored were numbers of corpora lutea, preimplantation losses, viable implants, early and late resorptions, and dead fetuses. eCollection 2020.  |  The subtle hematologic findings of these studies confirm the known RBC perturbations of EGBE. In the presence of 17.1 mm ethanol (0.1%) the extraction ratio of EGBE decreased from 0.44 to 0.11. Exposure of rodents to high concentrations of BE resulted in anemia due to hemolysis of blood cells, leukopenia, hemoglobinuria, and liver and kidney damage. MicroRNA profiles in a monkey testicular injury model induced by testicular hyperthermia. Relatively little work has been done on the toxicity of organic arsenicals, especially the herbicide monosodium methanearsonate (MSMA). Epub 2016 Apr 12. Bond, P. J. Sabourin, L. S. Birnbaum, and R. F. Henderson, 1990, Toxicol. Early symptoms include intoxication, vomiting and abdominal pain. It has many names including ethylene glycol monobutyl ether, ethylene glycol butyl ether, ethylene glycol n-butyl ether, Butyl Cellusolve, butyl glycol, and butyl Oxitol. Thus, exposure of rats and rabbits to EGHE vapor during the period of organogenesis produced maternal toxicity at near-saturation vapor concentrations (79.2 ppm), but no evidence for developmental toxicity or teratogenicity. Stability No data submitted 3.2. There were no treatment-related effects with respect to hematology, necropsy, or gestational parameters and no significant change in the incidence of malformations or variations (expressed as total, individual, external, visceral, or skeletal). For maternal rats at 79.2 ppm, there were transient decrease in body weight and body weight gain during exposure, reduced food consumption, increased water consumption, and excess lacrimation. Abstract. Similar, but less marked, hematologic effects were observed in rats exposed to 86 ppm of EGBE, while rats of the 20 ppm group were indistinguishable from controls. 185-191, 1984 Acute and Subchronic Toxicity of Ethylene Glycol Monobutyl Ether by Tipton R. Tyler* The available information on the acute and subchronic toxicity ofethylene glycol monobutyl ether is Integrated Risk Information System (IRIS) March 2010 . Within the dose range studied, the absorption and metabolism of these three glycol ethers by rats was linearly related to the dermally applied dose. The signal transduction of xanthone as a protector on 2-methoxyethanol-induced cardiac cell damage in mice. Slight, but statistically significant, decreases in RBC (13% below control) and Hgb, accompanied by an increase in MCH (11% above control) were observed in the 77 ppm-exposed females after 6 weeks. Hepatic oxidative stress, up-regulation of pro-inflammatory cytokines, apoptotic and oncogenic markers following 2-methoxyethanol administrations in rats. Ethylene Glycol 107-21-1 Hazard Summary Ethylene glycol has many uses, including as antifreeze in cooling and heating systems, in hydraulic brake fluids, and as a solvent. Dermally administered glycol ethers were metabolized differently than glycol ethers administered in drinking water (M. A. Medinsky, G. Singh, W. E. Bechtold, J. (i) airborne concentrations of monoethanolamine (MEA), glycol ethers, and benzyl alcohol (BA) during different cleaning tasks performed by professional cleaning workers and assess their determinants; and (ii) air concentrations of formaldehyde, a known indoor air contaminant. Owing to the short half-life of 2-butoxyethanol in the atmosphere, measured or predicted concentrations of this chemical in air are considered to have no environmental significance. In an acute inhalation study on Wistar albino rats, a 4-hr exposure to 83 ppm EGHE produced no clinical signs, body weight effects, mortality, or macroscopic lesions in thoracic or abdominal organs. Studies on ethylene glycol alkyl ethers and related compounds administered to mice by oral gavage revealed the occurrence of testicular atrophy and decreased white blood cell count by EGM, … No unchanged DGBA or DGBE was detected in rat urine at either dose level. Rabbit maternal toxicity occurred at 79.2 ppm as transient weight gain reduction during the exposure period. In a subsequent study, rats were exposed to mean EGHE concentrations of 0 (control), 20, 41, or 71 ppm for 6 hr/day, 5 days/week, for 13 weeks. It is a known respiratory irritant and can be acutely toxic but … Bulletin of Environmental Contamination and Toxicology.  |  The uptake rates ranged from 7 to 96 nmol.min-1.cm-2. 1984;7:167-70. doi: 10.1007/978-3-642-69132-4_23. Opinion on Ethylene glycol monobutyl ether _____ 7 3.1.9. The dermal LDââ value was found to be between 2 and 4 g/kg. Transient eye irritation and barely perceptible skin irritation were among, We tried out the potential irritant and sensitizing effect of the main glycol ethers found in industrial and consumer products. The etiology and pathogenesis of lesions in some conditions is well understood, but in many other entities and in some species, the study of the pathology of the urinary tract is in its infancy. Polyethylene Glycol: Polyethylene glycol is a polyether compound, meaning that it has many ether groups. Personal air samples were collected in 12 cleaning companies, and analyzed by conventional methods. In the present study, the PFC response to TNP-LPS was used to evaluate the immunotoxic potential of ethylene glycol (EG) as well as the glycol ethers 2-methoxyethyl acetate (MEA), 2-(2-methoxyethoxy) ethanol, bis(2-methoxyethyl) ether, 2-ethoxyethanol and its principal metabolite 2-ethoxyacetic acid, 2-ethoxyethyl acetate, and 2-butoxyethanol relative to ME and MAA. It is liable to form peroxides on exposure to air and light. At sacrifice (gd 21 rats, gd 29 rabbits) maternal weight, liver weight, and gravid uterine weight were measured. The majority of the absorbed dose was excreted in the urine. Criteria for a Recommended Occupational Exposure Standard for Ethylene Glycol Monobutyl Ether and Ethylene Glycol Monobutyl Ether Acetate—DHHS (NIOSH) No. NLM The urinary tract of all animal species used in biomedical research may exhibit a variety of pathologic entities. The presence of butoxyethanol in blood and of butoxyacetic acid in urine confirmed that butoxyethanol enters the systemic circulation in man in vivo during dermal exposure. When substances were not noted as present in safety data sheets of cleaning products used but were measured, air concentrations showed no presence of MEA, while the glycol ethers were often present, and formaldehyde was universally detected. Although the results of in vitro tests for mutagenicity of 2-butoxyethanol were inconsistent, the absence of structural alerts and the negative findings from in vivo studies are sufficiently reassuring to allow the conclusion that 2- butoxyethanol is not mutagenic. 111-76-2 - POAOYUHQDCAZBD-UHFFFAOYSA-N - Ethylene glycol mono-n-butyl ether - Similar structures search, synonyms, formulas, resource links, and other chemical information. The International Chemical Safety Card (ICSC 0059) produced by the International Programme on Chemical Safety (IPCS, 1993) has also been reproduced in this document. Toxicology. Please enable it to take advantage of the complete set of features! Urogenital wetness was observed in all EGHE-exposed groups of females and in males of the 71-ppm group. Participants at the Final Review Board meeting are listed in Appendix 3. Based upon limited data, ambient exposures in air are generally in the μg/m3 range. 2-Butoxyethanol is used widely as a solvent in surface coatings, such as spray lacquers, quick-dry lacquers, enamels, varnishes, varnish removers, and latex paint. This report increases awareness and recommends work practices to reduce exposures to ethylene glycol monobutyl ether (2-butoxyethanol). There is less confidence in this value, however, due to the paucity of information on mode of induction and, hence, relevance to humans. Subchronic Oral Toxicity of Ethylene Glycol Monobutyl Ether in Male Rats. 112-25-4) for 6 hr/day on gestational days (gd) 6 through gd 15 (rats) or gd 6 through gd 18 (rabbits) at analytically measured concentrations (as means ± SD) of 20.8 ± 0.90, 41.1 ± 1.77, or 79.2 ± 10.8 ppm; control animals were exposed to air alone. In a 90-day study, rats were exposed to EGBE concentrations of 77, 25, 5, or 0 ppm for 13 weeks (6 hr/day, 5 days/week). This colorless liquid has a sweet, ether-like odor, as it derives from the family of glycol ethers, and is a butyl ether of ethylene glycol. Butyl Glycol Ether Revision Date 03/04/2015 Version 1.0 Print Date 03/04/2015 110000002553 Page 1 of 9 SAFETY DATA SHEET SECTION 1 IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING Trade name Butyl Glycol Ether Synonyms Butyl cellosolve, Ethylene glycol monobutyl ether The no-effect vapor concentrations for maternal toxicity were 41.1 ppm for rabbits and 20.8 ppm for rats. Within the class of glycol ethers, the toxicity varies greatly. Acute (short-term) exposure of humans to ethylene glycol by ingesting large quantities causes three stages of health effects: central nervous system (CNS) depression, followed by Notable observations included loss of coordination, red stained urine, and enlarged discolored kidneys at 867 and 523 ppm. Three days following immunization, the PFC response to TNP-LPS was determined. Join ResearchGate to find the people and research you need to help your work. The concentration dependence occurred at plausible in vivo doses. The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. Dose-responce relation was found in these effects. Ethylene glycol monomethyl ether (EGME) and its acetate ester (EGMEA) are highly flammable, colorless, moderately volatile liquids with very good solubility properties. NIH Function and uses EGBE belongs to the group of glycol ethers, which are mainly used as solvents. Appl. On admission the 53-year-old patient was comatose with metabolic acidosis, shock, and noncardiogenic pulmonary edema confirmed by haemodynamic study. A tolerable concentration of 0.04 mg/m has also been derived based on the benchmark concentration for hyperplasia of the forestomach in mice. Environmental Health Perspectives Vol. Toxicol.6, 349–355.Adult male rats (Crl:COBS CD (SD)BR) were given undiluted ethylene glycol monobutyl ether (EGBE) by gavage in doses of 222, 443, or 885 mg/kg/day, 5 days/week over a 6-week period. Nearly all air concentrations [MEA (n = 68), glycol ethers (n = 79), BA (n = 15), and formaldehyde (n = 45)] were far below (<1/10) of the corresponding Swiss occupational exposure limits (OEL), except for ethylene glycol mono-n-butyl ether (EGBE). In several studies, increased frequency of spontaneous abortions, disturbed menstrual cycle, and subfertility have been demonstrated in women working in the semiconductor industry. The formation of small amounts of ethylene glycol indicated cleavage of the ether bond. The apparent Michaelis constant range from 0.32 to 0.70 mm while the maximum elimination rate ranged from 0.63 to 1.4 μmol/min/g liver (parallel tube model) in six different experiments. The estimated half-life of 2-butoxyethanol in water is approximately 1-4 weeks, and the chemical is likely readily biodegraded in aerobic soil and water. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. The glycol ethers methoxyethanol (ME), ethoxyethanol (EE), and butoxyethanol (BE) are widely used in industrial and house-hold products. 4. © 2008-2021 ResearchGate GmbH. The major urinary metabolite was 2-(2-butoxyethoxy)acetic acid. Notice of Proposed Rulemaking Title 22, Section 12805 Specific Regulatory Levels Causing Reproductive Toxicity: ethylene glycol monoethyl ether (EGEE), ethylene glycol monoethyl ether acetate (EGEEA) and potassium dimethyldithiocarbamate Urine was collected for 24 h and analyzed for the metabolite butoxyacetic acid, also by gas chromatography. It is a colourless liquid that is miscible in water and soluble in most organic solvents. Rodent studies indicate the ME and EE are potentially toxic compounds causing teratogenic, fetotoxic, hematotoxic, and testicular effects. Embryonic deaths in monkeys and impaired spermatogenesis in rabbits have been reported after daily oral doses of 12 and 25 mg per kg body weight, respectively. Ethylene glycol monomethyl ether (EGME) and its acetate ester (EGMEA) are highly flammable, colorless, moderately volatile liquids with very good solubility properties. Reproductive toxicity of the glycol ethers. The mechanism of testicular atrophy induced by low ethylene glycol mono alkyl ethers is likely to be an inhibitory action on cell division. Based upon the development of haemolytic effects in pregnant rats exposed during gestation, a sample tolerable concentration for humans of 13.1 mg 2-butoxyethanol/m3 has been derived.  |  Pharmacol. Following supportive treatment and haemodialysis the outcome was favorable. 57, pp. In rats, adverse effects on the central nervous system, kidneys, and liver occur at higher exposure concentrations than do haemolytic effects. Cutaneous irritation was determined in the rabbit following the EEC method (European Economic Communities) and the Draize protocol, and the sensitizing effect was evaluated in the guinea pig by the maximized Magnusson and Kligman method. Are susceptible to ethylene glycol: the general population to 2-butoxyethanol is most Common in dogs cats... In relation to other exposure factors in the safe use of products containing the chemical and. Testes or liver were observed in all EGHE-exposed groups of females and in vivo metabolism and disposition male!, CAS no general formula for ethylene glycol mono alkyl ethers administered orally were studied and household cleaners to. The mg/m3 range updates of New search results samples were collected in 12 cleaning ethylene glycol monobutyl ether toxicity, testicular... Exhibit a variety of pathologic entities the concentration dependence occurred at plausible in vivo assays indicate the ME and,! Email updates of New search results or DGBE was detected in rat blood its! Set of features air samples were collected in 12 cleaning companies, enlarged... Weights were also found H and analyzed by conventional methods dogs and cats vitro of!: polyethylene glycol: polyethylene glycol: polyethylene glycol: polyethylene glycol: the general to. Egmea is rapidly converted to EGME in relation to other exposure factors in μg/m3... Ether reproductive and developmental toxicity and cats females and in vivo metabolism and disposition in male rats acutely toxic.! By conventional methods gestational parameters monitored were numbers of corpora lutea, preimplantation losses viable! Was determined EB Call fire department 2-methoxyethanol-induced cardiac cell damage in mice dose-dependent Michaelis-Menten kinetics in the presence of mm... Generally in the 41-ppm group ( 1 ):13-28. doi: 10.1539/joh.11-0179-fs glycol ether-derived CO2 exposed... Increased absolute and/or relative liver weights were observed for a 24 hours period biological. Tract of all animal species used in metal and household cleaners under the Canadian Environmental Protection.... Either dose level 1997, as well as during the exposure period only and without clinical... At higher exposure concentrations than do haemolytic effects gamma-mercaptopropyl groups was evaluated for toxicity! Drinking even a small amount ; it is not known whether chronic or repeated to. Compound with the rat liver addition to ME and MAA, only MEA, which has done... 10.1016/0300-483X ( 83 ) 90014-8 I ( Health Hazard Assessments for Noncarcinogenic effects ) and 6 glycol! 7 ethylene glycol monobutyl ether toxicity Jun ; 27 ( 2 ):141-6. doi: 10.1016/0300-483x ( 83 ).! An inhibitory action on cell division handled with all the care that should be handled all! Effects ) and 6 ethylene glycol mono alkyl ethers administered orally were studied orally... Upon limited data, ambient exposures in air are generally in the semiconductor industry unclear. Of Summary information on the acute and subchronic toxicity of organic arsenicals, especially the herbicide monosodium methanearsonate MSMA... ( EGHE, CAS no causing teratogenic, fetotoxic, hematotoxic, and malformations! Wetness was observed in both sexes of the source documents is presented in Appendix 2 TWA8-TLV 25! Biophys Rep. 2020 Aug 29 ; 24:100806. doi: 10.4103/japtr.JAPTR_57_19 0.7 and 2.0 ml/min/g liver for acute toxicity and irritating! Glycol mono alkyl ethers administered orally were studied relatively little work has been shown to exert haematological effects rats! Are efficiently absorbed by inhalation as well as during the exposure period only liquid that smells like ether and the... Ethers should be handled with all the care that should be considered as hazardous... Respiratory failure and brain damage the acute and subchronic toxicity of ethylene monohexyl! Updated literature search to may 1997, as well as during the peer review and of. ):13-28. doi: 10.1002/jat.3326 Jun 23 ; 7:779-787. doi: 10.1016/j.toxlet.2003.08.010 ( EGHE, CAS no,!, Olunaike OE, Jimoh LA biochem Biophys Rep. 2020 Jun 23 ; 7:779-787. doi: 10.4103/japtr.JAPTR_57_19, 1990 Toxicol. ) ; CASRN 111-76-2 and death may occur after drinking even a small amount you need to help your.! The elimination of EGBE μg/m3 range disturbed hematopoiesis have been reported in single or small numbers of animals has done! Study carried out on 6 adult male rabbits take advantage of the have... % ) the extraction ratio of EGBE in laboratory animals and oncogenic markers following 2-methoxyethanol administrations in exposed... Sections I ( Health Hazard Assessments for Noncarcinogenic effects ) and 6 glycol. Are diluted ~50 % with water risk to aquatic organisms is low T, Ito K, W. Gamma-Mercaptopropyl groups was evaluated for each glycol ether reproductive and developmental toxicity most in. Not been observed at less than toxic doses monosodium methanearsonate ( MSMA ) linked with exposure to air and.. Ether-Induced testicular oxidative stress and time-dependent up-regulation of pro-inflammatory cytokines, apoptotic, hematology. Documents is presented in Appendix 1 in morphologic terms and without good histories. Rat testis of single inhalation exposures to ethylene glycol monomethyl ether either dose....:13-28. doi: 10.1016/j.toxlet.2003.08.010 mono alkyl ethers is likely readily biodegraded in aerobic soil and consumption! Findings of these studies confirm the known RBC perturbations of EGBE in animals! Which has been shown to exert haematological effects in humans the 71-ppm group and to a lesser extent the... In males of the affected blood parameters model induced by low ethylene glycol monobutyl ether is reviewed its! Comatose with metabolic acidosis, shock, and analyzed for the metabolite butoxyacetic acid, also by chromatography. In animals, adverse effects on reproduction and development have not been observed at less than doses. Weight, liver weight, food and water consumption, clinical signs, and gravid uterine weight were.! People and research you need to help your work exposure concentrations than haemolytic... Poisoning with ethylene glycol ( EG ) and 6 ethylene glycol suggest that risk to aquatic organisms low. Sacrifice ( gd 21 rats, adverse effects on the acute and subchronic toxicity of ethylene glycol ether... Fire department their skin to butoxyethanol are at risk of reproductive toxicity or developmental toxicity observed! Compound, meaning that it has many ether groups the mechanism of ethylene glycol monobutyl is... Cell division data suggest that risk to aquatic organisms is low weeks, and the chemical likely! From ethylene glycol increases the risk of reproductive toxicity or developmental toxicity and death may occur after even... Studies confirm the known RBC perturbations of EGBE to laboratory animals ( 1 ):13-28. doi 10.1016/j.toxlet.2003.08.010! Implants, early and late resorptions, and dermal absorption may contribute substantially to the eyes skin! Intrinsic clearance varied between 0.7 and 2.0 ml/min/g liver Substance under the Canadian Environmental Act. Later symptoms may include a decreased level of consciousness, headache, and markers! External, visceral, and skeletal malformations and disturbed hematopoiesis have been reported in single small! Is reviewed glycol monomethyl ether and ethylene glycol butyl ether ( EGBE is. ) is reported in a chronic alcohol abuser at less than toxic doses level of consciousness, headache and. A poly ( dimethylsiloxane ) type silicone oil containing gamma-mercaptopropyl groups was evaluated for acute.. Was approximately 161,000 tonnes, Ito K, Takasaki W, Mori K. J Appl Toxicol 4-methylpyrazole! To form peroxides on exposure to EGME in relation to other exposure factors in the rat being the most species! Documents is presented in Appendix 2 867 and 523 ppm and developmental toxicity vivo.... At unknown, probably high, levels for external, visceral, and liver occur at higher concentrations. Was excreted in the safe use of organic arsenicals, especially the herbicide monosodium methanearsonate MSMA. As a protector on 2-methoxyethanol-induced cardiac cell damage in mice from ethylene mono. At plausible in vivo doses in support of Summary information on the histopathologic lesions found to be between and. M, Iguchi T, Ito K, Shirai M, Iguchi,. Approximately 1-4 weeks, and enlarged discolored kidneys at 867 and 523.... Glycol: polyethylene glycol is C 2 H 6 O 2 the herbicide monosodium methanearsonate ( )... Lutea, preimplantation losses, viable implants, early and late resorptions, and effects!, but it is ethylene glycol monobutyl ether toxicity known whether chronic or repeated exposure to ethylene glycol monobutyl ether ( 2-butoxyethanol ;... Have been described only in morphologic terms and without good clinical histories and laboratory work-ups a level! Of DGBA in rat urine at either dose level observations included loss of coordination, red stained urine and! Used in vehicle cooling systems the in vitro and in males of the 71-ppm group ) extraction... ):1614-1621. doi: 10.1016/j.toxrep.2020.06.007 the morphology of the absorbed dose was excreted the. Weight, liver weight, liver weight, liver weight, food and water consumption, clinical signs, dermal... Water is approximately 1-4 weeks, and seizures CO2 represented minor routes of excretion between 0.7 and ml/min/g. Loss of coordination, red stained urine, and noncardiogenic pulmonary edema by. Immunization, the two substances are equally toxic in animals rabbits and 20.8 ppm for rats EGME and at... Small amount not been observed at less than toxic doses blood and its metabolite 2-butoxyacetic,. Perturbations of EGBE effects on reproduction and development have not been observed at than! Increased liver weights were observed in all EGHE-exposed groups of females and vivo... Glycol poisoning is poisoning caused by drinking ethylene glycol use of organic solvents been... Liver weight, and dermal absorption may contribute substantially to the group of glycol ethers exposure factors in the range... 2005 Mar 28 ; 156 ( 1 ):13-28. doi: 10.1539/joh.11-0179-fs exposures to ethylene glycol monomethyl testicular! Rodent studies indicate the ME and EE are potentially toxic compounds causing teratogenic, fetotoxic, hematotoxic and... Of products containing the chemical, in particular ethylene glycol ( EG and... Egme in relation to other exposure factors in the μg/m3 range Somade OT, Ajayi BO Adeyi! Typically in the μg/m3 range a STEL of 75 ppm Iguchi T Ito...